Improving outcomes with bivalirudin in primary percutaneous coronary intervention
نویسندگان
چکیده
منابع مشابه
Improving outcomes with bivalirudin in primary percutaneous coronary intervention.
Optimal pharmacotherapy is essential to realize the bestoutcomes in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). In this regard, effectively restoring reperfusion and maintaining the patency of the infarct artery after stenting requires a balance between the haemorrhagic risks and the ischaemic benefits of anticoagu...
متن کاملBivalirudin in percutaneous coronary intervention
Bivalirudin is a member of the direct thrombin inhibitor group of anticoagulants. It has been evaluated as an alternative to unfractionated and low-molecular-weight heparins in the settings of percutaneous coronary intervention (PCI) and acute coronary syndrome (ACS). Results of clinical trials to date suggest bivalirudin is a viable alternative to the use of a heparin combined with a glycoprot...
متن کاملBivalirudin, glycoprotein inhibitor, and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom.
AIMS The HORIZONS trial reported a survival advantage for bivalirudin over heparin-with-glycoprotein inhibitors (GPIs) in primary PCI for ST elevation myocardial infarction. This drove an international shift in clinical practice. Subsequent studies have produced divergent findings on mortality benefits with bivalirudin. We investigated this issue in a larger population than studied in any of th...
متن کاملThe Relation of Serum Bilirubin Level with the Severity and Complexity of Coronary Artery Disease and Long-term Outcomes in the Patients Undergoing Primary Percutaneous Coronary Intervention
Background and Aims: Bilirubin has been considered an antioxidant that protects against atherosclerosis. The aim of this study was to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (CAD) and long-term outcome in the patients undergoing primary percutaneous coronary intervention (PCI). Materials and Methods: This prospective coho...
متن کاملThe role of bivalirudin in percutaneous coronary intervention.
Bivalirudin (angiomax) is a reversible direct thrombin inhibitor. It is a polypeptide that has a carboxy-terminal region that recognizes thrombin’s fibrinogen-binding site, and an amino-terminal tetrapeptide that inhibits the active site of thrombin. It is considered superior to its prototype; hirudin as it is less dependent on renal function and has a lower incidence of anaphylaxis. Bivalirudi...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2014
ISSN: 1522-9645,0195-668X
DOI: 10.1093/eurheartj/ehu227